Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination
نویسندگان
چکیده
Citation: van der Lee S, van Rooijen DM, de Zeeuw-Brouwer M-L, Bogaard MJM, van Gageldonk PGM, Marinovic AB, Sanders EAM, Berbers GAM and Buisman AM (2018) Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination. Front. Immunol. 9:681. doi: 10.3389/fimmu.2018.00681 robust Humoral and Cellular immune responses to Pertussis in adults after a First acellular Booster Vaccination
منابع مشابه
Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control.
We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.
متن کاملWhole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
Introduction Pertussis is re-emerging worldwide, despite effective immunization programs for infants and children. Epidemiological studies show a more limited duration of protection against clinical pertussis in adolescents primed with acellular pertussis (aP) vaccines during infancy than those who have been primed with whole-cell pertussis (wP) vaccines. This study aimed to determine whether m...
متن کاملCellular immunity in adolescents and adults following acellular pertussis vaccine administration.
Cell-mediated immune (CMI) responses to an acellular pertussis vaccine administered to 49 subjects, a subset of participants in the National Institutes of Health-funded adult acellular pertussis vaccine efficacy trial, were evaluated and compared with antibody responses to vaccine antigens. Levels of proliferation of and cytokine secretion from lymphocytes cultured in the presence of pertussis ...
متن کاملPreliminary study on the immunogenicity of a newly developed GCC Tdap vaccine and its protection efficacy against Bordetella pertussis in a murine intranasal challenge model
PURPOSE Active reduced dose tetanus-diphtheria-acellular pertussis (Tdap) vaccination for adolescents and adults is necessary because waning immunity after primary diphtheria-tetanus-pertussis vaccination is related to the recent emergence of pertussis. This study was conducted to compare the immunogenicity and protection efficacy against Bordetella pertussis between a new GCC Tdap vaccine and ...
متن کاملImmune responses to pertussis antigens in infants and toddlers after immunization with multicomponent acellular pertussis vaccine.
Given the resurgence of pertussis despite high rates of vaccination with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine, a better understanding of vaccine-induced immune responses to Bordetella pertussis is needed. We investigated the antibody, cell-mediated, and cytokine responses to B. pertussis antigens in children who received the primary vaccination series (at 2, 4, and 6 months...
متن کامل